This paper develops a novel gorilla-derived oncolytic adenovirus, GRAd32Fk25, which selectively replicates in tumor cells and expresses a therapeutic antibody, showing potential as an improved virotherapy compared to HAd5.

bioRxiv · Mar 1, 2026 · PreprintCancer Biology

Non-clinical safety of GRAd vector-based COVID-19 and HIV vaccines supports a platform regulatory approach

Reji Paalangara, Stéphanie Gohin, Alexis Menard, Charlotte Amy, Wahiba Berrabah, Alexandra Rogue, Matthew A. Getz, Aljawharah Alrubayyi, Simone Battella, Angelo Raggioli, Michela Gentile, Anthea Di Rita, Alessia Noto, Giuseppina Miselli, Fabiana Grazioli, , Stefania Capone

This study evaluates the non-clinical safety of two GRAd vector-based vaccines for COVID-19 and HIV, showing consistent safety profiles and supporting a regulatory platform approach.

Vaccines · Feb 6, 2026Peer-reviewedPharmacology & Toxicology

Mouse model of the human serotonin transporter-linked polymorphic region

Łukasz Piszczek, Simone Memoli, Angelo Raggioli, José Viosca, Jeanette M. J. Rientjes, Philip Hublitz, Weronika Czaban, Anna Wyrzykowska, Cornelius Thilo Gross

The paper develops a mouse model of the human 5-HTT-LPR polymorphism to study its effects on gene expression, serotonin homeostasis, and behavioral traits.

Mammalian Genome · Oct 30, 2019Peer-reviewedNeuroscience

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

Laetitia Weinhard, Giulia Di Bartolomei, Giulia Bolasco, Pedro Machado, Nicole L. Schieber, Urtė Neniškytė, Melanie Exiga, Augustė Vadišiūtė, Angelo Raggioli, Andreas Schertel, Yannick Schwab, Cornelius Thilo Gross

This study identifies microglia-mediated synaptic remodeling through trogocytosis and filopodia induction in developing hippocampal cultures.

Nature Communications · Mar 26, 2018Peer-reviewedNeuroscience