Author

Laetitia Weinhard

European Molecular Biology LaboratoryORCID 0000-0003-2017-7746Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 4

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Approach:experimental assay· 4 Organism:mouse· 4 Research Focus:cell-cell communication· 2 Research Focus:differential expression· 2 Assay:imaging· 2 Research Focus:cell type annotation· 1 Research Focus:database / resource· 1 Assay:electronic health records· 1

Frequent Co-Authors

Cornelius Thilo GrossiD· 3 shared Giulia BolascoiD· 3 shared Alberto GalbuseraiD· 1 shared Alessandro GozziiD· 1 shared Andreas Schertel· 1 shared Angelo RaggioliiD· 1 shared Augustė VadišiūtėiD· 1 shared Bernadette BasilicoiD· 1 shared

Activity by Year

2018-2023 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersNeuroscience

Cornelius Thilo GrossORCID

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4 papers

Recent·Most cited

Microglia complement signaling promotes neuronal elimination and normal brain functional connectivity

Senthilkumar Deivasigamani, Mariya Timotey Miteva, Silvia Natale, Daniel Gutierrez‐Barragan, Bernadette Basilico, Silvia Di Angelantonio, Laetitia Weinhard, Dmitry A. Molotkov, Sukrita Deb, Constantin Pape, Giulia Bolasco, Alberto Galbusera, Hiroki Asari, Alessandro Gozzi, Davide Ragozzino, Cornelius Thilo Gross

This study shows that complement signaling via C3r is critical for perinatal neuronal elimination but not synaptic pruning in the developing brain.

Cerebral Cortex · Sep 8, 2023Peer-reviewedNeuroscience

Analysis of microglial BDNF function and expression in the motor cortex

Diana Honey, Erin Wosnitzka, Eric Klann, Laetitia Weinhard

The paper investigates microglial BDNF expression and its impact on neuronal activity and interactions in the motor cortex, finding that microglia do not express BDNF at levels sufficient to modulate neuronal function.

Frontiers in Cellular Neuroscience · Dec 23, 2022Peer-reviewedNeuroscience

Three-dimensional nanostructure of an intact microglia cell

Giulia Bolasco, Laetitia Weinhard, Tom Boissonnet, Ralph Neujahr, Cornelius Thilo Gross

This paper presents the first 3D ultrastructural reconstruction of an entire mouse hippocampal microglia using SBEM and CLEM, providing a reference for microglia cell biology.

Frontiers in Neuroanatomy · Dec 4, 2018Peer-reviewedNeuroscience

Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction

Laetitia Weinhard, Giulia Di Bartolomei, Giulia Bolasco, Pedro Machado, Nicole L. Schieber, Urtė Neniškytė, Melanie Exiga, Augustė Vadišiūtė, Angelo Raggioli, Andreas Schertel, Yannick Schwab, Cornelius Thilo Gross

This study identifies microglia-mediated synaptic remodeling through trogocytosis and filopodia induction in developing hippocampal cultures.

Nature Communications · Mar 26, 2018Peer-reviewedNeuroscience