Cornelius Thilo Gross

This study identifies reciprocal feedback inhibition and distinct intrinsic firing properties between two neuron classes in the mouse ventromedial hypothalamus involved in defensive behaviors.

The paper identifies glutamatergic and GABAergic neurons in the dPAG that encode both threat assessment and escape behaviors across different threat types.

The paper investigates the role of immediate early genes (IEGs) in social defeat-induced behavioral plasticity in the medial hypothalamus, finding that IEG activity is critical for adaptation and that NMDA receptor mechanisms may oppose this effect.

This study develops a protocol to induce territorial behaviors and dominance hierarchies in laboratory mice, revealing differences in hierarchy formation between strains.

This study shows that complement signaling via C3r is critical for perinatal neuronal elimination but not synaptic pruning in the developing brain.

The paper identifies midbrain projections to the cuneiform nucleus that induce flight behavior through optogenetic stimulation.

This study uses computational modeling to show that a simple inhibitory feedback circuit in the VMH can produce firing patterns resembling in vivo Assessment+ and Flight+ cells during threat response transitions.

The paper demonstrates that dAPEX2/DAB labeling is compatible with 3D volume EM techniques to map long-range synaptic inputs in the mouse brain.

This study shows that microglia regulate glutamatergic synapses in adult mouse hippocampus, with their removal causing reversible synaptic and behavioral changes.

This study uses pharmacogenetic inhibition to show that the cerebral cortex acutely suppresses innate defensive behaviors in response to threatening stimuli.

The paper identifies a neural circuit in mice that balances approach and avoidance behaviors during prey capture by linking lateral hypothalamus GABAergic neurons to periaqueductal grey neurons.

The paper investigates whether a conserved brain network involved in predator fear in rodents is also active in nonhuman primates during visually evoked predator fear.

This study investigates how predator fear is encoded in the ventromedial hypothalamus and periaqueductal grey using electrophysiological recordings in mice.

The paper identifies neurons in the mouse ventromedial hypothalamus that dynamically encode social threat and spatial context, showing functional reorganization after social defeat.

This study shows that maternal genotype influences global DNA methylation patterns in mice, with prenatal maternal effects driving differences between inbred strains.

The paper develops a mouse model of the human 5-HTT-LPR polymorphism to study its effects on gene expression, serotonin homeostasis, and behavioral traits.

This paper presents the first 3D ultrastructural reconstruction of an entire mouse hippocampal microglia using SBEM and CLEM, providing a reference for microglia cell biology.

This study identifies microglia-mediated synaptic remodeling through trogocytosis and filopodia induction in developing hippocampal cultures.