Aina Bernal

This study uses Perturb-seq to identify gene regulatory programs in HSPCs that link genetic regulators to cell biological processes and stem cell phenotypes.

The paper develops sc-lentiMPRA to analyze enhancer activity and specificity in single cells during differentiation, finding motif affinity influences TF response patterns.

The paper identifies design principles of cell-state specific enhancers by analyzing synthetic DNA sequences in hematopoietic differentiation.

This study identifies HASTER, a lncRNA that stabilizes HNF1A expression through cis-regulatory mechanisms, and shows its disruption leads to diabetes.