Robert Frömel

The paper develops sc-lentiMPRA to analyze enhancer activity and specificity in single cells during differentiation, finding motif affinity influences TF response patterns.

This study identifies conserved and diverged gene regulatory networks in mammalian cerebellum development using single-nucleus gene expression and chromatin accessibility data from six species.

This study uses biophysical models to show that transcription factors can act as activators, repressors, or both, with their effects influenced by binding affinity and regulatory context.

This study analyzes gene regulatory programs in primate gonads, finding shared and species-specific regulatory dynamics and candidate genes for sex development disorders.

This paper introduces EPI-clone, a method using DNA methylation to trace clonal lineages in hematopoiesis without genetic engineering, showing clonal complexity declines with age in mice and expands in humans.

The paper identifies design principles of cell-state specific enhancers by analyzing synthetic DNA sequences in hematopoietic differentiation.

This study maps the regulatory landscape of mouse cerebellum development using snATAC-seq, identifying cis-regulatory elements and their spatiotemporal dynamics.

The paper identifies and profiles leukemic and pre-leukemic stem cells using single-cell transcriptomics combined with lineage tracing via somatic variants.