Marissa Co

Detailed phenotyping of Tbr1-2A-CreER knock-in mice demonstrates significant impacts on TBR1 protein levels and axon development

This study evaluates the Tbr1-2A-CreER knock-in mouse line, showing reduced TBR1 protein levels and axon development issues, indicating it is a hypomorphic allele with implications for neurodevelopmental research.

Shared and distinct functional effects of patient-specific Tbr1 mutations on cortical development

This study examines the functional effects of two patient-specific Tbr1 mutations on cortical development in mice, revealing both shared and distinct phenotypes.

Expression of FoxP2 in the Basal Ganglia Regulates Vocal Motor Sequences in the Adult Songbird

This study shows FoxP2 in the basal ganglia is essential for fluent birdsong initiation, termination, and syllable sequencing, with disruptions affecting dopamine receptor balance and vocal-motor sequencing.

Autism-linked gene FoxP1 selectively regulates the cultural transmission of learned vocalizations

This study shows that FoxP1 selectively impairs social learning of vocalizations but not imitation in zebra finches, highlighting a specific vulnerability in cultural transmission.

Cortical Foxp2 supports behavioral flexibility and developmental dopamine D1 receptor expression

This study shows that cortical Foxp2 is essential for behavioral flexibility and dopamine D1 receptor expression, with effects on cell type composition and gene expression in the neonatal cortex.