Matthew J. Harper

Cell type-specific roles of FOXP1 in the excitatory neuronal lineage during early neocortical murine development

This study investigates the cell type-specific roles of FOXP1 in mouse neocortical development, revealing its impact on neurogenesis, gene expression, and cortical layering, with implications for ASD and FOXP1 syndrome.

FOXP1 regulates the development of excitatory synaptic inputs onto striatal neurons and induces phenotypic reversal with reinstatement

This study shows FOXP1 regulates glutamatergic input development in striatal neurons, with potential therapeutic implications for FOXP1 syndrome.

An extra-circadian function for human CLOCK in the neocortex

This study shows that human CLOCK has extra-circadian functions in the neocortex, enhancing cognitive flexibility and neural connectivity through altered gene expression in excitatory neurons.

Single-cell analysis of Foxp1-driven mechanisms essential for striatal development

This study uses single-cell RNA-sequencing to investigate Foxp1's role in striatal development, identifying cell-type-specific transcriptional mechanisms and functional deficits linked to FOXP1 mutations.

Cortical Foxp2 supports behavioral flexibility and developmental dopamine D1 receptor expression

This study shows that cortical Foxp2 is essential for behavioral flexibility and dopamine D1 receptor expression, with effects on cell type composition and gene expression in the neonatal cortex.