Kevin M. Wright

This study shows that ISL1 is essential for the terminal differentiation and maintenance of starburst amacrine cells in the mouse retina, affecting their identity, migration, and circuit development.

The paper identifies and characterizes four uncharacterized retinal ganglion cell subtypes using a combination of genetic labeling, molecular, morphological, and functional analyses.

This study shows that PTEN regulates the dendritic morphology of starburst amacrine cells during development, with Pten-deficient cells showing increased branching without affecting other properties.

This study examines sensory behaviors and transcriptomic changes in a Pten heterozygous mouse model of ASD, identifying altered somatosensory neuron development and subtype-specific marker expression.

This study shows that Dystroglycan's extracellular and intracellular domains have distinct roles in inhibitory synapse formation and maintenance in cerebellar Purkinje cells.

This study evaluates the Tbr1-2A-CreER knock-in mouse line, showing reduced TBR1 protein levels and axon development issues, indicating it is a hypomorphic allele with implications for neurodevelopmental research.

The paper evaluates Cre lines and a viral approach for conditional deletion in cerebellar Purkinje cells, showing variability in recombination efficiency and protein loss timing.

This study shows that Gbx2 regulates dendritic stratification of amacrine cells via Robo1/2 receptors and Slit1/2 ligands in the mouse retina.

This study examines inhibitory synapse defects and seizure susceptibility in mouse models of dystroglycanopathy, showing that severe forms exhibit impaired CCK+/CB1R+ interneuron development and synaptic function.

The paper shows that Aδ-low threshold mechanoreceptors form tiled receptive fields through competition for hair follicles during early postnatal development.

This study examines the functional effects of two patient-specific Tbr1 mutations on cortical development in mice, revealing both shared and distinct phenotypes.

The paper identifies a subtype of ipRGCs projecting to the SON and shows they encode ground luminance through a non-overlapping tiled mosaic in the dorsal retina.

This study identifies c-Kit as a key mediator of cutaneous sensory axon innervation and MKI-induced neurotoxicity through Src signaling in zebrafish and mice.

This study shows that Dystroglycan is essential for the postnatal development of CCK+ interneurons, as its deletion leads to their axonal misguidance and loss in specific brain regions.

The paper introduces sciMAP-ATAC, a method for spatially resolved single-cell chromatin accessibility profiling, and applies it to study cortical lamination, spatial trajectories, and ischemic infarct progression in mouse and human tissues.

This study shows that BAX is required for isoflurane-induced neuronal death in neonates, with GABAergic interneurons being selectively vulnerable and neuroinflammation secondary to apoptosis.

The paper identifies two distinct amacrine cell subtypes in the mouse retina using Gbx2, revealing their unique molecular, morphological, and physiological properties.

The paper introduces an improved single-cell ATAC-seq method, scip-ATAC-seq, which enhances chromatin dynamics analysis in human corticogenesis organoids.

This study identifies Dystroglycan as an extracellular scaffold that coordinates axon guidance by interacting with environmental cues and the receptor Celsr3/Adgrc3.

This study shows that dystroglycan is essential for proper sorting of retinal ganglion cell axons at the optic chiasm, with missorted axons persisting into adulthood.

This study identifies Cas adaptor proteins as essential for DRG axon fasciculation and substrate adhesion during peripheral nervous system development.

This study shows dystroglycan is critical for maintaining inner limiting membrane integrity, which coordinates retinal development and neuronal migration.