Author

Ian A. Roundtree

Harvard UniversityORCID 0000-0002-9791-054XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:human· 2 Assay:DNA methylation· 1 Research Focus:drug response / drug discovery· 1 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

Alan D. D’AndreaiD· 1 shared Astrid ZimmermanniD· 1 shared Bose S. KochupurakkaliD· 1 shared Cai‐Guang YangiD· 1 shared Chuan HeiD· 1 shared Geoffrey Ira ShapiroiD· 1 shared Gregory Michael CoteiD· 1 shared Guan‐Zheng LuoiD· 1 shared

Activity by Year

2019-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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1 shared paperCancer Biology

Alan D. D’AndreaORCID

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2 papers

Recent·Most cited

DNA-PK enforces the S/G2 checkpoint in ATM-deficient cells to limit ATR inhibitor efficacy

Timothy B. Branigan, Roshen Alharthi, Bose S. Kochupurakkal, Jie Hao, Steffie Revia, Joachim Albers, Mu-Yan Cai, Yuqing Jiao, Kelsey McQueen, Sirisha Mukkavalli, Ian A. Roundtree, Gregory Michael Cote, Prafulla C. Gokhale, Kalindi Parmar, Alan D. D’Andrea, , Geoffrey Ira Shapiro

This study shows DNA-PK enforces the S/G2 checkpoint in ATM-deficient cells, reducing ATR inhibitor efficacy, and suggests combining ATR and DNA-PK inhibition could enhance treatment in such cancers.

bioRxiv · Oct 28, 2026 · PreprintCancer Biology

Single-base mapping of m6A by an antibody-independent method

Zhang Zhang, Li-Qian Chen, Yuli Zhao, Cai‐Guang Yang, Ian A. Roundtree, Zijie Scott Zhang, Jian Min Ren, Wei Xie, Chuan He, Guan‐Zheng Luo

This paper introduces an antibody-independent method for single-base m6A mapping, showing high reliability and conservation across species.

Science Advances · Jul 3, 2019Peer-reviewedGenetics