Author

Xiyu Liu

Harold C. Simmons Comprehensive Cancer CenterORCID 0000-0002-6803-2696Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Genetics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:clustering· 1 Assay:CRISPR screen· 1 Approach:deep learning· 1 Research Focus:differential expression· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Emilija AleksandroviciD· 2 shared Hazel M. BorgesiD· 2 shared Kevin M. DeaniD· 2 shared Samantha M. GolombiD· 2 shared Siyuan ZhangiD· 2 shared Wei MaiD· 2 shared Ateş Kutay TenekeciiD· 1 shared Dailin GaniD· 1 shared

Activity by Year

2026-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 42 mutual co-author links

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2 shared papersGenetics

Emilija AleksandrovicORCID

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2 papers

Recent·Most cited

GeneticsbioRxivPreprintOct 9, 2026

Niche-dependent epistasis within the cancer genome shapes metastatic fitness

Xiyu Liu, Le He, Min Zhao…·Siyuan Zhang

The paper maps gene-by-gene-by-environment epistasis in cancer metastasis using CRISPR perturbations in mice, showing niche-dependent fitness and transcriptome convergence.

DOI 10.64898/2026.10.02.756296

mouseCRISPR screen

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Cancer BiologyNature CommunicationsPeer-reviewedSep 3, 2026

Tumor-Intrinsic IFNγ Signaling and Niche Adaptation Drive Early Colonization in Ovarian Cancer Metastasis

Emilija Aleksandrovic, Shaneann R. Fross, Samantha M. Golomb…·Siyuan Zhang

This study identifies tumor-intrinsic IFNγ signaling and niche adaptation as key drivers of early colonization in ovarian cancer metastasis using MetTag, a single-cell barcoding approach.

DOI 10.1038/s41467-026-77222-8

mousescRNA-seq

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