Author

Le He

Harold C. Simmons Comprehensive Cancer CenterORCID 0009-0002-7488-0947Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1

Signature Assays, Organisms & Methods

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Assay:CRISPR screen· 1 Approach:experimental assay· 1 Organism:mouse· 1 Research Focus:perturbation response prediction· 1

Frequent Co-Authors

Dailin GaniD· 1 shared Emilija AleksandroviciD· 1 shared Gary C. HoniD· 1 shared Hao ZhuiD· 1 shared Hazel M. BorgesiD· 1 shared Jun LiiD· 1 shared Kevin M. DeaniD· 1 shared Lei Wang· 1 shared

Activity by Year

2026-2026 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperGenetics

Dailin GanORCID

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1 paper

Recent·Most cited

GeneticsbioRxivPreprintOct 9, 2026

Niche-dependent epistasis within the cancer genome shapes metastatic fitness

Xiyu Liu, Le He, Min Zhao…·Siyuan Zhang

The paper maps gene-by-gene-by-environment epistasis in cancer metastasis using CRISPR perturbations in mice, showing niche-dependent fitness and transcriptome convergence.

DOI 10.64898/2026.10.02.756296

mouseCRISPR screen

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