Author

Q Doctrove

University of MichiganORCID 0000-0002-6811-8828Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genetics· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:drug response / drug discovery· 1 Organism:human· 1 Organism:mouse· 1

Frequent Co-Authors

Ahmed Mujtaba MalikiD· 1 shared Christie A. Gillies· 1 shared Guy M. LenkiD· 1 shared Haoran HuangiD· 1 shared Josephine J. WuiD· 1 shared MH Meisler· 1 shared Sami J. BarmadaiD· 1 shared VH LiPuma· 1 shared

Activity by Year

2022-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperNeuroscience

Ahmed Mujtaba MalikORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

GeneticsbioRxivPreprintApr 28, 2026

CRISPR activation of PIKFYVE as potential therapy for FIG4 deficiency

Q Doctrove, Guy M. Lenk, VH LiPuma, MH Meisler

This study uses CRISPR activation to upregulate PIKFYVE in Fig4 deficient mice, showing that a 2-fold increase is insufficient to rescue lysosomal enlargement and survival.

DOI 10.64898/2026.04.24.718784

mouseexperimental assay

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NeurosciencebioRxivPreprintApr 11, 2022

Neuronal activity regulates Matrin 3 levels and function in a calcium-dependent manner through calpain cleavage and calmodulin binding

Ahmed Mujtaba Malik, Josephine J. Wu, Christie A. Gillies…·Sami J. Barmada

This study shows that neuronal activity regulates MATR3 levels and function through calpain cleavage and Ca2+/calmodulin binding, linking these processes to ALS pathology.

1 citation

humanexperimental assay

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