Rafiq Huda

The paper presents a low-cost, modular, open-source hardware and software platform for head-fixed mouse decision-making tasks, reducing experimenter labor and enabling scalable animal training.

The paper shows that striatal ACh and DA drive astrocyte Ca2+ activity, which is disrupted in Parkinsonian mice, suggesting astrocytes as a therapeutic target.

This study investigates how DLS astrocytes contribute to EtOH-induced stimulation and drinking behavior through calcium signaling and cholinergic interactions in mice.

This study identifies the anterior cingulate cortex (ACC) as a key cortical region modulating arousal states through optogenetic experiments and behavioral measurements.

This study shows that activating astrocytes in the dorsal striatum improves motor deficits in Parkinson's disease mice by enhancing their calcium activity and behavioral performance.

This study shows that neuronal DAMPs activate astrocytic RIPK3 signaling, leading to neuroinflammation and dopaminergic cell death in Parkinson's disease.

This paper develops a method for binge-like ethanol consumption in head-fixed mice and uses two-photon calcium imaging to study its effects on prefrontal cortex neuron activity.

The paper develops a novel foraging task to study action-outcome associations in mice, revealing that striosomal neurons encode reinforcement outcomes more strongly than matrix neurons.

This study shows that voluntary alcohol consumption disrupts the coupling between prefrontal cortical activity and arousal in mice.

This study identifies distinct roles of prefrontal cortex projections in modulating sensorimotor behavior through separate circuits for motor response coordination and sensory cue processing.

The paper uses 2-photon imaging to show striosomes and matrix in the striatum have distinct roles in reinforcement learning by encoding reward-predicting cues and expected outcomes.