Brian P. Daniels

This study shows SIRT1 promotes viral replication in astrocytes during orthoflavivirus infection by altering metabolism and NAD+ salvage.

This study shows that astrocytic RIPK3 reduces inflammation in viral encephalitis by increasing serpin protease inhibitors, improving survival and BBB integrity.

This study shows RIPK3 drives antiviral transcription in neurons during ZIKV infection, while inducing cell death in MEFs, with RHIM domain interactions mediating these context-dependent functions.

This study shows that neuronal DAMPs activate astrocytic RIPK3 signaling, leading to neuroinflammation and dopaminergic cell death in Parkinson's disease.

This study identifies RIPK3's role in promoting neuronal survival during CNS viral infection by suppressing excitatory neurotransmission, independent of its traditional necroptotic function.

This study shows ZIKV infection alters neurologic gene expression linked to psychiatric disorders through TNF-α signaling in neurons and mouse models.

This study shows that α-synuclein fibrils activate midbrain astrocytes through RIP kinase and NF-κB signaling, leading to neurotoxicity and inflammation in Parkinson's disease.

This study develops a human brain organoid model with controllable microglia ratios to better model brain development and pathology.