Collagen I promotes cancer cell survival via amino acid import and mTORC1 activation
Mona Nazemi, Bian Yanes, Ifeoluwa Feyisayo Oyelade, Heather J. Walker, Elena Rainero
This study shows collagen I supports cancer cell survival by activating mTORC1 and enhancing amino acid import through LAT1-4F2hc, which is linked to poor prognosis in breast and pancreatic cancers.
bioRxiv · Nov 26, 2025 · PreprintCancer Biology