Coessential Genetic Networks Reveal the Organization and Constituents of a Dynamic Cellular Stress Response
David R. Amici, Daniel J. Ansel, Kyle A. Metz, Roger S. Smith, Claire M. Phoumyvong, Sitaram Gayatri, Tomasz Chamera, Stacey L. Edwards, Brendan P. O’Hara, Shashank Srivastava, Sonia Brockway, Seesha R. Takagishi, Byoung-Kyu Cho, Young Ah Goo, Neil L. Kelleher, , Marc L. Mendillo
The paper constructs a coessential genetic network to map the dynamic cellular stress response across 625 cancer cell lines, identifying key regulators and modules involved in stress resilience.
Proceedings of the National Academy of Sciences · Jul 1, 2022Peer-reviewedGenetics