Author

Shah Saddad Hussain

University of Alabama at BirminghamORCID 0000-0002-6830-2924Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cell Biology· 1 Physiology· 1

Signature Assays, Organisms & Methods

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Research Focus:cell type annotation· 2 Research Focus:differential expression· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1

Frequent Co-Authors

Jacelyn E. Peabody LeveriD· 2 shared Javier CamposiD· 2 shared Kevin S. HarrodiD· 2 shared Scott E. PhillipsiD· 2 shared Steven Mark RoweiD· 2 shared Denise D. StanfordiD· 1 shared Dezhi WangiD· 1 shared Emily Falk Libby· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 41 mutual co-author links

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2 shared papersPhysiology

Jacelyn E. Peabody LeverORCID

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2 papers

Recent·Most cited

Pulmonary Fibrosis Ferret Model Demonstrates Sustained Fibrosis, Restrictive Physiology, and Aberrant Repair

Jacelyn E. Peabody Lever, Qian Li, Nikoleta Pavelková, Shah Saddad Hussain, Sayan Bakshi, Janna Ren, L. I. Jones, Kajal Jadhav, Jared P. Kennemur, Mason Weupe, Javier Campos, Liping Tang, Jeremie M. Lever, Dezhi Wang, Denise D. Stanford, , Steven Mark Rowe

This study shows that bleomycin-exposed ferrets develop sustained pulmonary fibrosis, restrictive lung physiology, and airway remodeling similar to human IPF.

npj Regenerative Medicine · Nov 27, 2025Peer-reviewedPhysiology

ACE-2 Blockade & TMPRSS2 Inhibition Mitigate SARS-CoV-2 Severity Following Cigarette Smoke Exposure in Airway Epithelial Cells In Vitro

Shah Saddad Hussain, Emily Falk Libby, Jacelyn E. Peabody Lever, Jennifer L. Tipper, Scott E. Phillips, Marina Mazur, Qian Li, Javier Campos, Kevin S. Harrod, Steven Mark Rowe

This study shows that cigarette smoke increases ACE-2 and TMPRSS2 expression in airway cells, enhancing SARS-CoV-2 infection, which is mitigated by ACE-2 blockade and TMPRSS2 inhibition.

Molecular Therapy — Nucleic Acids · Jun 2, 2025Peer-reviewedCell Biology