Cell BiologyMolecular Therapy — Nucleic AcidsPeer-reviewed
ACE-2 Blockade & TMPRSS2 Inhibition Mitigate SARS-CoV-2 Severity Following Cigarette Smoke Exposure in Airway Epithelial Cells In Vitro
Shah Saddad Hussain, Emily Falk Libby, Jacelyn E. Peabody Lever…·Steven Mark Rowe
This study shows that cigarette smoke increases ACE-2 and TMPRSS2 expression in airway cells, enhancing SARS-CoV-2 infection, which is mitigated by ACE-2 blockade and TMPRSS2 inhibition.