Steven Mark Rowe

This study shows that bleomycin-exposed ferrets develop sustained pulmonary fibrosis, restrictive lung physiology, and airway remodeling similar to human IPF.

This study shows that cigarette smoke increases ACE-2 and TMPRSS2 expression in airway cells, enhancing SARS-CoV-2 infection, which is mitigated by ACE-2 blockade and TMPRSS2 inhibition.

This study compares a novel CFTR potentiator, SK-POT1, to ivacaftor in improving mucociliary clearance in airway epithelial cells exposed to cigarette smoke.

The study identifies loss of cell junctions and matrix dysregulation as drivers of epithelial desquamation and fibrosis in IPF distal bronchioles.

This study develops an antisense oligonucleotide (ASO) therapy for CF patients with the 3849+10kb C-to-T splicing mutation, showing restoration of CFTR function in patient-derived cells.