Author

Skyler L. Kelly

University at Buffalo, State University of New YorkORCID 0000-0002-6841-0044Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biochemistry· 1 Biophysics· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:bacteria (other)· 1 Research Focus:cell type annotation· 1 Assay:cryo-EM· 1 Assay:DNA methylation· 1 Organism:E. coli· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Andrew S. NorrisiD· 1 shared Courtney E. SzyjkaiD· 1 shared Eric J. StrobeliD· 1 shared Haoyun YangiD· 1 shared Katie LichtenthaliD· 1 shared Kye StachowskiiD· 1 shared Mark P. FosteriD· 1 shared Paul GollnickiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 29 mutual co-author links

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1 shared paperBiophysics

Andrew S. NorrisORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Sequential structure probing of cotranscriptional RNA folding intermediates

Courtney E. Szyjka, Skyler L. Kelly, Eric J. Strobel

This study introduces TECprobe-LM to directly assess cotranscriptional RNA folding rearrangements by sequentially probing nascent RNA structures in E. coli.

Nature Communications · May 31, 2025Peer-reviewedBiochemistry

Structural basis of nearest-neighbor cooperativity in the ring-shaped gene regulatory protein TRAP from protein engineering and cryo-EM

Weicheng Li, Haoyun Yang, Kye Stachowski, Andrew S. Norris, Katie Lichtenthal, Skyler L. Kelly, Paul Gollnick, Vicki Hopper Wysocki, Mark P. Foster

This study investigates nearest-neighbor cooperativity in TRAP by engineering dTRAP variants and using cryo-EM and thermodynamic analyses to reveal structural and thermodynamic mechanisms of ligand binding cooperativity.

Proceedings of the National Academy of Sciences · Dec 30, 2024Peer-reviewedBiophysics