Weicheng Li

This study identifies small molecule inhibitors of APOBEC3A and APOBEC3B using a fluorescence polarization assay, revealing compounds that disrupt DNA interactions and deaminase activity.

This study develops small molecules that activate the tumor suppressor kinase LKB1 and shows their therapeutic benefits in cancer cell lines.

The paper identifies a small molecule, BRD1732, that is ubiquitinated in cells, leading to proteasome inhibition through accumulation of ubiquitin chains.

This study investigates nearest-neighbor cooperativity in TRAP by engineering dTRAP variants and using cryo-EM and thermodynamic analyses to reveal structural and thermodynamic mechanisms of ligand binding cooperativity.