BiophysicsProceedings of the National Academy of SciencesPeer-reviewed
Structural basis of nearest-neighbor cooperativity in the ring-shaped gene regulatory protein TRAP from protein engineering and cryo-EM
Weicheng Li, Haoyun Yang, Kye Stachowski…·Mark P. Foster
This study investigates nearest-neighbor cooperativity in TRAP by engineering dTRAP variants and using cryo-EM and thermodynamic analyses to reveal structural and thermodynamic mechanisms of ligand binding cooperativity.
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