Author

Haopeng Xiao

Harvard UniversityORCID 0000-0002-4166-647XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Biochemistry· 1 Cell Biology· 1 Molecular Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:mouse· 3 Assay:proteomics· 3 Research Focus:differential expression· 2 Research Focus:drug response / drug discovery· 2 Approach:experimental assay· 2 Organism:human· 2 Research Focus:protein structure prediction· 2 Approach:statistical model· 2

Frequent Co-Authors

Edward T. ChouchaniiD· 3 shared Bingsen ZhangiD· 2 shared Nils BurgeriD· 2 shared Sanghee ShiniD· 2 shared Shelley M WeiiD· 2 shared Adam L. OrriD· 1 shared Anna G. OrriD· 1 shared Caroline BooraemiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersCell Biology

Edward T. ChouchaniORCID

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Redox activation of ATG5 licenses autophagy upon nutrient restriction

Sanghee Shin, Ekaterina D. Korobkina, Claudia Lennicke, Nils Burger, Bingsen Zhang, Haopeng Xiao, Yaoyu Wang, Jonathan J. Petrocelli, Shelley M Wei, David Wood, Lei Yu, Xiaomei Zhang, María C. Pérez-Matos, Muneeb A Sharif, Jiuchun Zhang, , Edward T. Chouchani

The paper identifies redox regulation of ATG5's Cys19 as critical for autophagy initiation under nutrient restriction in human cells and mice.

bioRxiv · Sep 24, 2026 · PreprintCell Biology

Diverse bacterial pattern recognition receptors sense the core phage proteome

Hyunbin Lee, Sofia Luengo-Woods, Jianxiu Zhang, Kira S. Makarova, Yuri I. Wolf, Collin Chiu, Simone A. Evans, Junyi Chen, Haopeng Xiao, Liang Feng, Eugene V. Koonin, Linyi Gao

The paper identifies 90 structurally distinct STAND NTPase families in bacteria and archaea that recognize phage proteins, revealing their role in antiviral defense.

Nature · Jul 29, 2026Peer-reviewedMolecular Biology

A druggable redox switch on SHP1 controls macrophage inflammation

Mei Ying Ng, Meredith Nicole Nix, Guangyan Du, Ivan Davidek, Nils Burger, Sanghee Shin, Sean T. Toenjes, Haruna Takeda, Megan Cheah Xin Yan, Bingsen Zhang, Haopeng Xiao, Shelley M Wei, Hyuk‐Soo Seo, Sirano Dhe‐Paganon, Thomas E. Wales, , Edward T. Chouchani

This paper identifies a druggable redox switch on SHP1 that controls macrophage inflammation by developing a covalent agonist targeting a specific cysteine residue.

Nature Chemical Biology · Mar 12, 2026Peer-reviewedBiochemistry

Mitochondrial complex III-derived ROS amplify immunometabolic changes in astrocytes and promote dementia pathology

Daniel Barnett, Till S. Zimmer, Caroline Booraem, Fernando Palaguachi, Samantha M. Meadows, Haopeng Xiao, Man Ying Wong, Wenjie Luo, Li Gan, Edward T. Chouchani, Anna G. Orr, Adam L. Orr

This study identifies mitochondrial complex III-derived ROS as a key driver of immunometabolic changes in astrocytes that contribute to dementia pathology.

Nature Metabolism · Nov 4, 2025Peer-reviewedNeuroscience