Author

Erick E Nakagaki-Silva

University of CambridgeORCID 0000-0002-6878-4409Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Christopher W. J. SmithiD· 3 shared Clare GoodingiD· 3 shared Yi An YangiD· 2 shared Adrian Buckroyd· 1 shared Aishwarya G. JacobiD· 1 shared Frederick Richards· 1 shared Giselle C. LeeiD· 1 shared Katherine M. StottiD· 1 shared

Activity by Year

2019-2023 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 26 mutual co-author links

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3 shared papersMolecular Biology

Christopher W. J. SmithORCID

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3 papers

Recent·Most cited

Molecular BiologybioRxivPreprintJan 23, 2023

Mechanism of an alternative splicing switch mediated by cell-specific and general splicing regulators

Yi An Yang, Giselle C. Lee, Erick E Nakagaki-Silva…·Christopher W. J. Smith

The paper shows how a cell-specific RBP, RBPMS, collaborates with general splicing regulators to control alternative splicing by remodeling RNA-protein complexes.

1 citation

experimental assay

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Molecular BiologyNucleic Acids ResearchPeer-reviewedNov 11, 2022

Phosphorylation of the Smooth Muscle Master Splicing Regulator RBPMS Regulates its Splicing Activity

Michael D. Barnhart, Yi An Yang, Erick E Nakagaki-Silva…·Christopher W. J. Smith

This study shows that phosphorylation of RBPMS at Thr113 and Thr118 reduces its splicing activity, mediated by ERK2, and may regulate SMC splicing during vascular injury.

14 citations

humanproteomics

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Molecular BiologyeLifePeer-reviewedJul 8, 2019

Identification of RBPMS as a smooth muscle master splicing regulator via proximity of its gene with super-enhancers

Erick E Nakagaki-Silva, Clare Gooding, Miriam Llorian…·Christopher W. J. Smith

The paper identifies RBPMS as a master splicing regulator in vascular smooth muscle cells by analyzing its proximity to super-enhancers and its role in alternative splicing during phenotypic switching.

45 citations

mousebulk RNA-seq

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