Author
The Francis Crick InstituteORCID 0000-0002-1794-3094Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Jingkun Zeng, Zhiyuan Cheng, Huadong Chen…·Jennifer A. Doudna
This paper develops a method to selectively kill cancer cells with TP53 mutations by using RNA-guided Cas12a2 to induce chromatin shredding through targeting cancer-specific transcripts.
James A. W. Stowell, Conny Wing-Heng Yu, Zhuo Angel Chen…·Lori A. Passmore
The paper shows phosphorylation modulates deadenylation rates via multivalent interactions in RNA adaptors, enabling graded regulation of mRNA decay.
Berta Canal, Agostina P. Bertolin, Guan Hwee Bernard Lee…·John F.X. Diffley
This study reveals DNA replication fork stabilization and restart mechanisms using biochemical reconstitution in budding yeast.
Yi An Yang, Giselle C. Lee, Erick E Nakagaki-Silva…·Christopher W. J. Smith
The paper shows how a cell-specific RBP, RBPMS, collaborates with general splicing regulators to control alternative splicing by remodeling RNA-protein complexes.