Clare Gooding

Mechanism of an alternative splicing switch mediated by cell-specific and general splicing regulators

The paper shows how a cell-specific RBP, RBPMS, collaborates with general splicing regulators to control alternative splicing by remodeling RNA-protein complexes.

Phosphorylation of the Smooth Muscle Master Splicing Regulator RBPMS Regulates its Splicing Activity

This study shows that phosphorylation of RBPMS at Thr113 and Thr118 reduces its splicing activity, mediated by ERK2, and may regulate SMC splicing during vascular injury.

Identification of RBPMS as a smooth muscle master splicing regulator via proximity of its gene with super-enhancers

The paper identifies RBPMS as a master splicing regulator in vascular smooth muscle cells by analyzing its proximity to super-enhancers and its role in alternative splicing during phenotypic switching.

Heteromeric RNP assembly at LINEs controls lineage-specific RNA processing

The paper shows that LINE repeat sequences recruit RNA-binding proteins to repress splicing and 3' end processing in introns, contributing to lineage-specific RNA processing in mammals.