Christopher W. J. Smith

The paper shows how a cell-specific RBP, RBPMS, collaborates with general splicing regulators to control alternative splicing by remodeling RNA-protein complexes.

This study shows RBPMS induces contractile splicing patterns and alters phenotypic behavior in human embryonic stem cell-derived vascular smooth muscle cells.

This study shows that phosphorylation of RBPMS at Thr113 and Thr118 reduces its splicing activity, mediated by ERK2, and may regulate SMC splicing during vascular injury.

The paper uses spliceosome iCLIP to map human spliceosome engagement with snRNAs and pre-mRNAs, identifying over 50,000 branchpoints and their associated splicing factor binding patterns.

The paper identifies RBPMS as a master splicing regulator in vascular smooth muscle cells by analyzing its proximity to super-enhancers and its role in alternative splicing during phenotypic switching.

The paper shows that LINE repeat sequences recruit RNA-binding proteins to repress splicing and 3' end processing in introns, contributing to lineage-specific RNA processing in mammals.