Megan A. Sheridan

This study identifies ZIKV proteins that downregulate AXL and TIM-1 via autophagy, enhancing viral replication and spread by preventing superinfection and dampening innate immunity.

The paper identifies a uNK-derived cytokine signal that promotes trophoblast differentiation and influences placental function and pregnancy outcomes.

This paper develops properly-polarized trophoblast stem cell-derived organoids that mimic the in vivo placental structure, enabling better modeling of placental development and maternal-fetal interactions.

This study creates a spatially resolved single-cell multiomics atlas of human trophoblast differentiation in early pregnancy, revealing key regulatory programs and cell-cell communication events involved in EVT invasion and arterial transformation.