Autophagy-Mediated Downregulation of AXL and TIM-1 Promotes Sustained Zika Virus Infection
Jingyou Yu, Yi-Min Zheng, Megan A. Sheridan, Pei Li, Toshihiko Ezashi, R. Michael Roberts, Shan‐Lu Liu
This study identifies ZIKV proteins that downregulate AXL and TIM-1 via autophagy, enhancing viral replication and spread by preventing superinfection and dampening innate immunity.
Proceedings of the National Academy of Sciences · May 23, 2025Peer-reviewedMicrobiology