Toshihiko Ezashi

This study identifies ZIKV proteins that downregulate AXL and TIM-1 via autophagy, enhancing viral replication and spread by preventing superinfection and dampening innate immunity.

This paper develops properly-polarized trophoblast stem cell-derived organoids that mimic the in vivo placental structure, enabling better modeling of placental development and maternal-fetal interactions.

This paper develops an optimized protocol for large-scale production of human blastoids and identifies signaling pathways and endometrial stromal effects in blastocyst development.