Jinping Lei

PeTFlow designs peptides by optimizing sequence, conformation, and side-chain packing using flow-matching and state tokenization, achieving high-quality results on benchmarks.

SynPROTAC generates novel PROTAC molecules with feasible synthetic routes and favorable properties using a synthesis-constrained generative model and reinforcement learning.

DiffDec generates structure-aware R-groups for molecular scaffolds using a diffusion model, achieving higher recovery rates and better binding affinity than existing methods.