SynPROTAC: synthesizable PROTACs design through synthesis constrained generative model and reinforcement learning
Mingyuan Xu, Chaoming Huang, Li Pang, Qirui Deng, Hao Zhang, Anjie Qiao, Zhiwen Luo, Zhen Wang, Chang‐Yu Hsieh, Z Zhang, Tie‐Gen Chen, Hongming Chen, Jinping Lei
SynPROTAC generates novel PROTAC molecules with feasible synthetic routes and favorable properties using a synthesis-constrained generative model and reinforcement learning.
JACS Au · Jul 7, 2026Peer-reviewedBioinformatics