A Sequence Motif Enables Widespread Use of Non-Canonical Redox Cofactors in Natural Enzymes
Samer Saleh, Ning-Hsiang Hsu, Emma Luu, Vincent C. Martin, Hans Jefferson C. Ng, William B. Black, Jin‐Kwang Kim, Banumathi Sankaran, Ryan L. Hayes, Justin B. Siegel, Feng Qiao, Han Li
The paper identifies a conserved sequence motif that enables natural enzymes to use non-canonical redox cofactors, demonstrating high activity with NMN+ and other synthetic cofactors.
bioRxiv · Aug 1, 2025 · PreprintSynthetic Biology