Samer Saleh

Machine learning guided cell-free expression maps the biochemical landscape of carbonic anhydrase

The paper uses machine learning to guide cell-free expression of carbonic anhydrases, identifying variants with improved stability under high temperatures.

Expanding the scope of redox-balance growth coupling techniques with a carbon cofeeding strategy

This paper introduces a carbon cofeeding strategy to overcome stoichiometric limitations in redox-balance growth coupling, enabling growth-coupled selection for biosynthetic pathways in engineered E. coli.

A Sequence Motif Enables Widespread Use of Non-Canonical Redox Cofactors in Natural Enzymes

The paper identifies a conserved sequence motif that enables natural enzymes to use non-canonical redox cofactors, demonstrating high activity with NMN+ and other synthetic cofactors.

Activation-Free Upgrading of Carboxylic Acids to Aldehydes and Alcohols

This paper demonstrates an activation-free method to convert carboxylic acids to aldehydes and alcohols using aldehyde dehydrogenases, achieving high yields and carbon efficiency.