Integrating collecting systems in kidney organoids through fusion of distal nephron to ureteric bud.
Min Yan Shi, Brittney Crouse, Nambirajan Sundaram, Naomi Pode‐Shakked, Lioba Ester, Weitao Zhang, Vinothini Janakiram, Raphael Kopan, Michael A. Helmrath, Joseph Vincent Bonventre, Kyle W. McCracken
This paper describes a method to integrate collecting systems in kidney organoids by fusing distal nephron with ureteric bud tissues, enabling functional nephrons with continuous epithelial lumens.
bioRxiv · Sep 19, 2024 · PreprintDevelopmental Biology