Dorothea Seiler Vellame

Methylomic signatures of tau and amyloid-beta in transgenic mouse models of Alzheimer's disease neuropathology

The paper identifies DNA methylation changes in transgenic mouse models of Alzheimer's disease, showing distinct patterns for tau and amyloid-beta pathology and some overlap with human AD data.

DNA methylation signatures of Alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types

The paper identifies DNA methylation signatures in Alzheimer's disease cortex, showing most changes are driven by non-neuronal cell types.

Uncertainty quantification of reference based cellular deconvolution algorithms

This paper introduces and validates a metric to assess the accuracy of cellular deconvolution in DNA methylation studies, showing it identifies biases in different demographic groups.

Characterizing the properties of bisulfite sequencing data: maximizing power and sensitivity to identify between-group differences in DNA methylation

The paper develops a simulation framework and tool to assess and optimize power for detecting DNA methylation differences in bisulfite sequencing studies.