Zeshan Ahmed

Methylomic signatures of tau and amyloid-beta in transgenic mouse models of Alzheimer's disease neuropathology

The paper identifies DNA methylation changes in transgenic mouse models of Alzheimer's disease, showing distinct patterns for tau and amyloid-beta pathology and some overlap with human AD data.

Glymphatic Inhibition Exacerbates Tau Propagation in an Alzheimers Disease Model

This study shows that inhibiting the glymphatic system worsens tau spread and memory issues in a mouse model of Alzheimer's disease.

Long-read transcript sequencing identifies differential isoform expression in the entorhinal cortex in a transgenic model of tau pathology

The paper uses long-read transcript sequencing to identify differential isoform expression in the entorhinal cortex of tau transgenic mice, revealing novel isoforms and transcript associations with tau pathology.

Full-length transcript sequencing of human and mouse identifies widespread isoform diversity and alternative splicing in the cerebral cortex

This study uses long-read RNA sequencing to analyze isoform diversity in human and mouse cerebral cortex, revealing widespread alternative splicing and novel transcripts.

Differential aberrant structural synaptic plasticity in axons and dendrites ahead of their degeneration in tauopathy

This study tracks synapse plasticity in tauopathy and finds that changes in synaptic structure precede neurite degeneration, with distinct patterns in axons and dendrites.

Imbalance in the response of pre- and post-synaptic components to amyloidopathy

The paper examines how Aβ plaques develop and affect synaptic density and turnover in a mouse model of Alzheimer's disease, finding an imbalance in pre- and post-synaptic responses.

Transcriptional signatures of progressive neuropathology in transgenic tau and amyloid mouse models.

This study identifies transcriptional changes in tau and amyloid mouse models, revealing gene expression patterns linked to AD pathology and immune response.