Author

Paul T. Francis

King's College LondonORCID 0000-0001-8159-4469Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Organism:human· 6 Research Focus:differential expression· 5 Approach:statistical model· 5 Assay:DNA methylation· 4 Approach:experimental assay· 2 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:drug response / drug discovery· 1

Frequent Co-Authors

Alan J. ThomasiD· 3 shared Eilis J. HannoniD· 3 shared Gemma L. ShirebyiD· 3 shared Jonathan S. MilliD· 3 shared Katie LunnoniD· 3 shared Kevin MorganiD· 3 shared Rebecca G. SmithiD· 3 shared Seth LoveiD· 3 shared

Activity by Year

2019-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersGenomics

Alan J. ThomasORCID

Mutual co-authors in cluster

Author profile →

7 papers

Recent·Most cited

Why diabetes matters in dementia studies. Excluding diabetes status masks regional mitochondrial DNA copy number changes in human hippocampus, amygdala, and cerebellum in Alzheimers disease

Aakruti Arun Kaikini, Anqi Shi, Paul T. Francis, Russell Howard Swerdlow, Claire Troakes, Jaimee Kennedy, Alan Hodgkinson, Afshan N. Malik

The paper shows that diabetes status affects mitochondrial DNA copy number changes in AD brain regions, with non-diabetic AD cases showing reduced mtDNA-CN and diabetic cases showing increased mtDNA-CN.

bioRxiv · Jun 8, 2026 · PreprintNeuroscience

DNA methylation signatures of Alzheimer's disease neuropathology in the cortex are primarily driven by variation in non-neuronal cell-types

Gemma L. Shireby, Emma Louise Dempster, Stefania S S Policicchio, Rebecca G. Smith, Ehsan Pishva, Barry A. Chioza, Jonathan P. Davies, Joe Burrage, Katie Lunnon, Dorothea Seiler Vellame, Seth Love, Alan J. Thomas, Keeley J. Brookes, Kevin Morgan, Paul T. Francis, , Jonathan S. Mill

The paper identifies DNA methylation signatures in Alzheimer's disease cortex, showing most changes are driven by non-neuronal cell types.

Nature Communications · Sep 24, 2022Peer-reviewedGenetics

A meta-analysis of epigenome-wide association studies in Alzheimer's disease highlights novel differentially methylated loci across cortex

Rebecca G. Smith, Ehsan Pishva, Gemma L. Shireby, Adam R. Smith, Janou A. Y. Roubroeks, Eilis J. Hannon, Greg Wheildon, Diego Mastroeni, Gilles Gasparoni, Markus J. Riemenschneider, Armin Giese, Andrew J. Sharp, Leonard C. Schalkwyk, Vahram H. Haroutunian, Wolfgang Viechtbauer, , Katie Lunnon

This study performs a meta-analysis of DNA methylation data from Alzheimer's disease patients to identify differentially methylated loci across brain regions and cortex.

Nature Communications · Jun 10, 2021Peer-reviewedGenomics

Dispersed Sleep Microstates and Associated Structural Changes in GBA1 Mouse: Relevance to Rapid Eye Movement Behavior Disorder

Çiğdem Gelegen, Diana Cash, Katarina Ilić, Millie Sander, Eugene Kim, Camilla Simmons, Michel Bernanos, Joana Lama, Karen Randall, Jon T. Brown, Svjetlana Kalanj Bognar, Samuel F. Cooke, К. Ray Chaudhuri, Clive G. Ballard, Paul T. Francis, Ivana Rosenzweig

The paper shows REM and NREM sleep abnormalities and structural changes in GBA1 mice, linking them to RBD and alpha-synucleinopathy progression.

bioRxiv · May 26, 2021 · PreprintNeuroscience

Recalibrating the Epigenetic Clock: Implications for Assessing Biological Age in the Human Cortex

Gemma L. Shireby, Jonathan P. Davies, Paul T. Francis, Joe Burrage, Emma Walker, Grant W. A. Neilson, Aisha Dahir, Alan J. Thomas, Seth Love, Rebecca G. Smith, Katie Lunnon, Meena Kumari B, Leonard C. Schalkwyk, Kevin Morgan, Keeley J. Brookes, , Jonathan S. Mill

The paper develops a novel DNA methylation clock optimized for human cortex tissue, outperforming existing clocks and highlighting issues with previous associations between DNA methylation age and neurodegenerative phenotypes.

Brain · Sep 15, 2020Peer-reviewedGenomics

Patient-specific Alzheimer-like pathology in trisomy 21 cerebral organoids reveals BACE2 as a gene-dose-sensitive AD-suppressor in human brain

Ivan Alić, Pollyanna Agnes Goh, Aoife Murray, Erik Portelius, Eleni Gkanatsiou, Gillian Gough, Kin Ying Mok, David Koschut, Reinhard Brunmeir, Yee Jie Yeap, Niamh Louise O’Brien, Jürgen Groet, Xiaowei Shao, Steven Havlicek, Norris Ray Dunn, , Henrik Zetterberg

The paper shows that trisomy 21 cerebral organoids exhibit AD-like pathology, which can be suppressed by BACE2 trisomy and inhibited by BACE1 inhibitors, suggesting BACE2 as an AD-suppressor gene.

Molecular Psychiatry · Jul 9, 2020Peer-reviewedNeuroscience

Identifying Novel Candidates for Re-Purposing as Potential Therapeutic Agents for Alzheimer’s disease

Clive G. Ballard, Byron Creese, Ariana P. Gatt, Patrick Doherty, Paul T. Francis, D Whitfield, Anne Corbett, J Corcoran, Diane P. Hanger, Sandrine Thuret, Richard Killick, Gareth Haydn Williams

The paper identifies 19 compounds from the CMAP library that show significant inverse correlation with Alzheimer's disease transcriptome signatures and pass in vitro screening assays.

bioRxiv · Apr 29, 2019 · PreprintNeuroscience