Adam R. Smith

This study examines how systemic respiratory infections alter transcriptional patterns in the Alzheimer's disease brain, identifying gene expression changes and pathways linked to immune and vascular responses.

The paper identifies DNA methylation changes in transgenic mouse models of Alzheimer's disease, showing distinct patterns for tau and amyloid-beta pathology and some overlap with human AD data.

This study identifies two epigenomic subtypes of late-onset Alzheimer's disease with distinct microglial and neuronal methylation signatures, linking them to different inflammatory and functional pathways.

This study identifies neuron-specific DNA methylation changes in Parkinson's disease prefrontal cortex, revealing hypermethylation at seven novel loci and highlighting the importance of cell-type-specific analysis.

CEAM is a tool for analyzing DNA methylation data to identify cell type-specific patterns, validated on neurodegenerative disease datasets.

The paper identifies a DNA methylation module in the substantia nigra associated with depressive symptoms in Parkinson's disease.

The paper develops a multivariate methylation risk score using blood DNA methylation data to predict dementia risk and cognitive impairment in Alzheimer's and Parkinson's disease cohorts.

This study performs a meta-analysis of DNA methylation data from Alzheimer's disease patients to identify differentially methylated loci across brain regions and cortex.

This study identifies widespread H3K27ac acetylomic variation in AD cases compared to controls, linking it to disease-related pathways and AD-associated genetic variants.