Parkinson's disease-related Miro1 mutation induces mitochondrial dysfunction and loss of dopaminergic neurons in vitro and in vivo
Axel Chemla, Giuseppe Arena, Ginevra Sacripanti, Kyriaki Barmpa, Alise Žagare, Pierre Garcia, Vyron A. Gorgogietas, Paul M. A. Antony, Jochen Ohnmacht, Alexandre Baron, Jaqueline Jung, Frida Lind‐Holm Mogensen, Alessandro Michelucci, Anne‐Marie Marzesco, Manuel Buttini, , Cláudia Saraiva
This study shows that a Miro1 mutation causes mitochondrial dysfunction and dopaminergic neuron loss in both cell models and mice, supporting its role in Parkinson's disease.
Brain · Feb 5, 2025Peer-reviewedNeuroscience