Kyriaki Barmpa

This study creates vascularized midbrain organoids to model Parkinson's disease, showing increased neuroinflammation and dopaminergic neuron vulnerability in patient-derived assembloids.

This study shows that a Miro1 mutation causes mitochondrial dysfunction and dopaminergic neuron loss in both cell models and mice, supporting its role in Parkinson's disease.

This paper introduces midbrain-striatum assembloids with inducible aging to model early Parkinson's disease phenotypes and nigrostriatal connectivity.

This study integrates human iPSC-derived microglia into midbrain organoids, enhancing neuronal maturation and functionality through effects on synaptic remodeling and excitability.

This study shows that HP-β-CD treatment improves dopaminergic differentiation in PD patient-derived midbrain organoids by enhancing mitophagy.