María Jesús Macías

The paper studies the conformational landscapes of full-length Smad2 and Smad4 proteins using an integrative approach and identifies their dynamic structural states and functional implications.

The paper presents the first structures of Drosophila germline-specific Thioredoxins, Dhd and TrxT, revealing unique structural features and their potential roles in redox regulation and chromatin remodeling.

This paper investigates the dimer/monomer propensities of Smad MH1-DNA complexes using structural biology methods, revealing that loop1 sequence determines dimerization and influencing Smad complex composition and DNA motif recognition.

The paper designs a Cortistatin analog with improved immunoregulatory activity for treating inflammatory bowel disease by optimizing its structure and stability.