The paper studies the conformational landscapes of full-length Smad2 and Smad4 proteins using an integrative approach and identifies their dynamic structural states and functional implications.

bioRxiv · Apr 13, 2021 · PreprintMolecular Biology

Structures of the germline-specific Deadhead and Thioredoxin T proteins from Drosophila melanogaster reveal unique features among Thioredoxins

Regina Freier, Eric Aragón, Błażej Bagiński, Radosław Pluta, Pau Martín-Malpartida, Lidia Ruiz, Miriam Condeminas, Cayetano González, María Jesús Macías

The paper presents the first structures of Drosophila germline-specific Thioredoxins, Dhd and TrxT, revealing unique structural features and their potential roles in redox regulation and chromatin remodeling.

IUCrJ · Feb 10, 2021Peer-reviewedMolecular Biology

Unveiling the dimer/monomer propensities of Smad MH1-DNA complexes

Lidia Ruiz, Zuzanna Kaczmarska, Tiago Gomes, Eric Aragón, Carles Torner, Regina Freier, Błażej Bagiński, Pau Martín-Malpartida, Natàlia de Martín Garrido, José Antonio Márquez, Tiago N. Cordeiro, Radosław Pluta, María Jesús Macías

This paper investigates the dimer/monomer propensities of Smad MH1-DNA complexes using structural biology methods, revealing that loop1 sequence determines dimerization and influencing Smad complex composition and DNA motif recognition.

Computational and Structural Biotechnology Journal · Jan 1, 2021Peer-reviewedMolecular Biology