Hironori Sugiyama

This study identifies a novel feedback system regulating Cdk function through Spo12, a small disordered protein that inhibits PP2A, and shows its role in enhancing cell proliferation in fission yeast.

This study measures cyclin-CDK dissociation constants in living cells using FCCS with optimized fluorescent proteins, revealing insights into cyclin-CDK binding redundancy.

The paper uses a topology-based theory to predict and validate independent control of G2-M and G1-S checkpoints in fission yeast cell cycle by analyzing CDK-cyclin complex dynamics.

This study applies the SLIPT system to fission yeast to perturb cell cycle-related proteins with improved temporal resolution.