Regulation of cell proliferation by a novel feedback system on Cdk function
Joseph C. Ryan, Baptiste Leray, Akanksha Jain, Nelson Coehlo, Maria Rosa Domingo-Sananes, Théo Aspert, Gilles Charvin, Matthias Krockenberger, Nathalia Chica, Sandra López‐Avilés, Luca Takacs, Frank Uhlmann, Ludong Yang, Jia‐Xing Yue, Gianni Liti, , Damien Y. M. Coudreuse
This study identifies a novel feedback system regulating Cdk function through Spo12, a small disordered protein that inhibits PP2A, and shows its role in enhancing cell proliferation in fission yeast.
bioRxiv · Oct 28, 2025 · PreprintCell Biology