Hai Yan Huang

KCNQ channels enable reliable presynaptic spiking and synaptic transmission at high-frequency

The paper shows that KCNQ channels help maintain stable presynaptic action potential waveforms during high-frequency firing, supporting reliable synaptic transmission in rat calyx of Held nerve terminals.

Kv7 channel antagonists block glycine receptors

This study shows that XE991, a Kv7 channel antagonist, also blocks glycine receptors, affecting both synaptic and exogenous glycine responses.

Activity and cytosolic Na+ regulates synaptic vesicle endocytosis

The paper shows that cytosolic Na+ accelerates synaptic vesicle endocytosis during high-frequency firing without affecting Ca2+ influx or exocytosis.

Spike activity regulates vesicle filling at a glutamatergic synapse

The paper shows that Na+ accumulation during high-frequency spiking activates a Na+/H+ exchanger on synaptic vesicles, enhancing glutamate loading and synaptic transmission reliability.

Astrocytes amplify neuronal dendritic volume transmission

The paper reveals a novel retrograde signaling mechanism in CRF neurons where astrocytes amplify dendritic volume transmission by responding to norepinephrine-induced ATP release.