Laurence O. Trussell

The paper shows that in the auditory system, EAATs rapidly remove glutamate to enable stimulus intensity coding in T-stellate cells, unlike their typical role in maintaining background glutamate levels.

The paper identifies molecular logic underlying cellular specializations in the cochlear nuclear complex using single-nucleus RNA sequencing and Patch-seq.

This study investigates how noise-induced hearing loss affects Ca2+-dependent spontaneous bursting activity in lateral olivocochlear neurons, finding increased burst duration and altered ion channel function.

The paper identifies calcium-sensitive subthreshold oscillations in fusiform cells of the mouse dorsal cochlear nucleus, showing they arise from intrinsic neuronal properties and gap junctions, and are modulated by extracellular calcium.

This study identifies NALCN as an excitatory leak channel modulated by α2-adrenergic and GABAB receptors to regulate spontaneous activity and synaptic strength in auditory neurons.

The paper investigates electrical activity in lateral olivocochlear neurons, finding an intrinsic calcium-dependent oscillator that generates slow spike bursts, regulated by synaptic inputs.

The paper shows that KCNQ channels help maintain stable presynaptic action potential waveforms during high-frequency firing, supporting reliable synaptic transmission in rat calyx of Held nerve terminals.

This study shows that XE991, a Kv7 channel antagonist, also blocks glycine receptors, affecting both synaptic and exogenous glycine responses.

The paper investigates synaptic plasticity in ascending and descending pathways to MOC neurons, finding opposing short-term plasticity and a wide dynamic range of firing.

The paper shows that ambient glutamate in the synaptic cleft modulates synaptic responses in cerebellar unipolar brush cells through glutamate transporters.

The paper identifies a new inhibitory neuron class, L-Stellate cells, in the ventral cochlear nucleus using transgenic mice and imaging techniques, showing their distinct morphology and functional role in auditory processing.

The paper shows that primary afferents selectively connect to ON unipolar brush cells, while secondary afferents connect to both ON and OFF subtypes, revealing distinct anatomical pathways for signal transformation.