Encoded metabolic remodeling amplifies drug resistance in Mycobacterium tuberculosis
Abigail M Frey, Gregory H. Babunovic, Peter H. Culviner, Xin Wang, Ella Meirav, Mingyu Gan, Junhao Zhu, David Branch Moody, Qingyun Liu, Sarah M. Fortune
This study identifies idsA2 mutations as a mechanism of ethambutol resistance in Mtb by showing they enhance drug resistance through metabolic remodeling.
PLoS Pathogens · Aug 14, 2026Peer-reviewedMicrobiology