Junhao Zhu

Reduced recombination relative to mutation characterizes dominant circulating clones of Mycobacterium abscessus

The paper analyzes genomic diversity in Mycobacterium abscessus, finding that dominant clones show increased accessory-gene gains and reduced recombination relative to mutation after establishment.

Encoded metabolic remodeling amplifies drug resistance in Mycobacterium tuberculosis

This study identifies idsA2 mutations as a mechanism of ethambutol resistance in Mtb by showing they enhance drug resistance through metabolic remodeling.

Parallel Emergence and Adaptive Evolution of Multicountry Circulating Mycobacterium abscessus Clones

The paper analyzes global M. abscessus genomes to show that recently emerged clones spread across countries and show shifts in selective pressures during expansion.

Label-free Pathogen Identification with Microscopy Imaging and Deep Learning

This paper develops a label-free imaging and deep learning approach to rapidly identify pathogens, achieving high accuracy in clinical samples and reducing diagnosis time.

RNA polymerase-mediated regulation of intrinsic antibiotic resistance and bacterial cell division

This study identifies a novel mechanism by which rifampin shortens TB treatment by inhibiting Mtb RNA polymerase, leading to cell division arrest and reduced antibiotic resistance.

IL-17A-driven Macrophage Disorder Promotes Plaque Instability in Psoriatic Atherosclerosis

This study shows IL-17A promotes plaque instability in psoriatic atherosclerosis by enhancing macrophage inflammation and disrupting lipid metabolism.