Author

Samuel Zinga

Harvard UniversityORCID 0000-0002-4633-8299Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 3 Organism:bacteria (other)· 2 Research Focus:host-pathogen & immune response· 2 Organism:human· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Eric J. RubiniD· 3 shared Claudia Maria DenkingeriD· 2 shared Ian D. WolfiD· 2 shared Kerry McGoweniD· 2 shared Mark R. SullivaniD· 2 shared Tobias FunckiD· 2 shared Alfred Lewis GoldbergiD· 1 shared Bertrand D. E. RaynaliD· 1 shared

Activity by Year

2025-2026 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 30 mutual co-author links

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3 shared papersMicrobiology

Eric J. RubinORCID

Mutual co-authors in cluster

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3 papers

Recent·Most cited

Activation Mechanism and Structural Assembly of the Mycobacterium tuberculosis ClpP1P2 Protease and Its Associated ATPases.

Katharina Weinhäupl, Tatos N. Akopian, Dmitry A. Semchonok, Olga Krandor, Rocío Arranz, M. Teresa Bueno-Carrasco, Marcos Gragera, Maelenn Chevreuil, Bertrand D. E. Raynal, Samuel Zinga, Yuxin Liu, Jack Hung-Sen Lai, Wengen Wu, William W. Bachovchin, Diego F. Gauto, , Hugo Fraga

This study identifies trehalose as an activator of ClpC1P1P2 and ClpXP1P2 protease complexes in Mycobacterium tuberculosis, revealing a new mechanism for in vivo activation without the need for peptide activators.

Cell Reports · May 30, 2026Peer-reviewedBiochemistry

Ribosomal protection as a linezolid resistance mechanism in Mycobacterium abscessus

Tobias Funck, Kerry McGowen, Mark R. Sullivan, Samuel Zinga, Ian D. Wolf, Dennis Nurjadi, Claudia Maria Denkinger, Eric J. Rubin

This study identifies an ABC-F protein in Mycobacterium abscessus that confers resistance to linezolid and other ribosome-targeting antibiotics.

Antimicrobial Agents and Chemotherapy · Mar 2, 2026Peer-reviewedMicrobiology

Efflux pumps and membrane permeability contribute to intrinsic antibiotic resistance in Mycobacterium abscessus

Kerry McGowen, Tobias Funck, Xin Wang, Samuel Zinga, Ian D. Wolf, Chidiebere Akusobi, Claudia Maria Denkinger, Eric J. Rubin, Mark R. Sullivan

The paper identifies membrane permeability and efflux pumps as key mechanisms of intrinsic antibiotic resistance in Mycobacterium abscessus and highlights potential targets for improving antibiotic efficacy.

PLoS Pathogens · Apr 10, 2025Peer-reviewedMicrobiology